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Chloramphenicol: Mechanism of action 【USMLE, biochemistry】

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This animation video shows the mechanism of action of chloramphenicol.

Chloramphenicol binds to the bacterial ribosomal 50S subunit (A site). This binds interferes with peptide transferase activity.

(Reference)
1. Identification of Human UGT2B7 as the Major Isoform Involved in the O-Glucuronidation of Chloramphenicol
Mei Chen, Barbara LeDuc, Stephen Kerr, David Howe and David A. Williams
Drug Metabolism and Disposition March 2010, 38 (3) 368-375; DOI: https://doi.org/10.1124/dmd.109.029900

2. Chloramphenicol. Pubchem. NIH. U.S. National Library of Medicine.
https://pubchem.ncbi.nlm.nih.gov

3. James Marks, Krishna Kannan, Emily J. Roncase, Dorota Klepacki, Amira Kefi, Cédric Orelle, Nora Vázquez-Laslop, and Alexander S. Mankin
Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center
PNAS October 25, 2016 113 (43) 12150-12155

4. "Chloramphenicol". The Merck Manual. Merck. Archived from the original on 2010-03-10.

5. Frank Schlünzen, et al. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature vol.413,814–821 (25 October 2001)

6. Chloramphenicol. Science Direct
sciencedirect.com

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50 Comments

    Popular Comments:

Prasenjit Shae . 2020-01-10
Kya esekhane se jaundice hota hai.
121 2 . Reply
Luke Schneider . 2019-07-14
This shit is POISON... CHLORINE KILLS ALL BACTERIA... GOOD ONES TOO....
121 2 . Reply
Dr. Chat Perche MD, PhD . 2018-10-31
Please let me know what you think about this video?
121 2 . Reply